New research shows that Ozempic and similar medications could help men with obesity or Type 2 diabetes boost their testosterone levels. The findings come from SSM Health St. Louis University Hospital, where a team studied 110 men who were using GLP-1 receptor agonists, such as semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), or tirzepatide (Zepbound).
These men were around 54 years old and were not using testosterone replacement or other hormone therapy. Over an 18-month period, they lost about 10% of their body weight on average. During that time, the number of men with normal testosterone levels rose from 53% to 77%.
The increase in testosterone was not as large as that seen with hormone therapy, but it came naturally. The men avoided many of the risks tied to direct testosterone treatment. The research points to a strong link between better weight control and improved hormone health in men.
Dr. Shellsea Portillo Canales, the lead researcher, said this is one of the first studies to show that GLP-1 medications may help reverse low testosterone caused by obesity. Earlier research showed that surgery or lifestyle changes could raise testosterone, but this new study highlights a possible non-surgical, medication-based option.
Low testosterone—also called hypogonadism—can lead to many health issues. Men with low levels often have low energy, reduced sex drive, weaker muscles, and mood changes. Long-term effects may include bone loss, heart problems, and trouble with blood sugar control.
Obesity and Type 2 diabetes can make testosterone drop even faster. Excess belly fat can interfere with hormone signals and convert testosterone into estrogen, lowering the hormone further. That’s why treatments that target weight loss may also help with hormone balance.
GLP-1 receptor agonists like Ozempic work by copying a hormone that helps control blood sugar and reduce appetite. These medications are usually given by injection once a week. They help the pancreas release insulin, lower blood sugar, slow digestion, and reduce hunger.
The study found that the weight lost by using these drugs may be what helps testosterone return to normal. Less fat in the body—especially around organs—can reduce inflammation and improve insulin resistance. This may help the body make more testosterone on its own.
It’s important to note that this study looked at past health records. That means it can’t prove that the medication alone caused the testosterone increase. Other factors, like better diet or exercise, might also have played a role. More research is needed to confirm these results.
Experts say GLP-1 medications could help a specific group: men with obesity or diabetes who also have low testosterone. In the U.S. and Canada, Ozempic is approved for Type 2 diabetes. Wegovy and Zepbound are approved for obesity or overweight adults with related conditions like high blood pressure.
Doctors advise caution when using testosterone therapy for slightly low levels. Instead, treating obesity or diabetes first may naturally improve hormone levels and avoid risks like acne, sleep apnea, reduced sperm count, or prostate issues.
Men already on hormone therapy might need to adjust their treatment if they start using GLP-1 medications and their testosterone levels return to normal. Anyone considering these drugs should speak with a doctor to see if they’re a good fit. Side effects may include nausea, vomiting, or diarrhea. Rarely, people may develop pancreatitis or kidney problems.
GLP-1 medications are not for everyone. They are not approved in some countries just for weight loss. People without obesity or diabetes should first focus on diet and exercise. If they stop using the medication, they might gain the weight back and lower their testosterone again. That’s why long-term healthy habits are key.
Men with a history of thyroid disease, pancreatitis, or kidney issues should avoid these drugs. Also, using them for appearance-related reasons may promote unhealthy views on weight.
This new study highlights a shift in how doctors might treat low testosterone linked to obesity. By focusing on body weight, inflammation, and insulin resistance, these drugs may help improve both metabolic and hormone health. While more research is needed, the results give hope to men looking for a safer and more natural option than hormone therapy.
For men dealing with obesity and low energy, this could mean more than just losing weight. It may bring back hormonal balance, improve mood, and support better overall health.